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Amlodipine, a Ca channel blocker commonly used for hypertension and angina, has been reported to inhibit the PI3K/Akt and Raf/MEK/ERK pathways via the epidermal growth factor receptor (EGFR) and regulate cell cycle-related proteins, such as cyclin D1, p-Rb, p27, and p21

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Hence, we chose only a single concentration of QCT (2 mg/kg) based on a prior study 44 , a relatively low dose compared to the commonly used range of 10100 mg/kg 45,46 , for our in vivo experiments

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